Table 1. Expression and Role of Myoepithelial Cell Markers in Breast Tumors: Benign Breast Epithelial Tumors vs. Carcinoma in Situ vs. Invasive Carcinoma
Note:
1. Benign glandular ducts or ductal carcinoma in situ are often surrounded by myoepithelial cells (except for microglandular adenoma, which is S100+), while in invasive carcinoma, myoepithelial cells disappear.
2. In invasive carcinoma, it stimulates the tissue to produce myofibroblasts or fibroblasts surrounding the tumor periphery, and expression of SMA, Calponin, etc., must be differentiated from carcinoma in situ.
3. The nuclear expression of P63 shows punctate negativity, which may result in the loss of some points due to sectioning issues.