Farewell Tumor: A Self-Narrative of SMARCA4-Deficient Tumors

The SMARCA4 protein is encoded by the 19p13 gene and is one of the two mutually exclusive ATPase subunits in the SWI/SNF complex. Loss of this protein can lead to the development of various cancers, including non-small cell lung cancer, thoracic sarcoma, and ovarian small cell carcinoma with hypercalcemia. These tumors are relatively rare, highly malignant, and aggressive. Immunohistochemistry aids in their diagnosis and differential diagnosis, particularlyThe application of SMARCA4 antibody markers will facilitateenabling patients to benefit from precise diagnosis as early as possible.